Is cytidine a deaminase?
Table of Contents
The systematic name of this enzyme class is cytidine/2′-deoxycytidine aminohydrolase. This enzyme participates in pyrimidine metabolism. As every deoxycytidine deaminase is also a cytidine deaminase, they share the same EC number.
What is the substrate for the cytidine deaminase enzyme?
Cytidine Deaminase Substrates
| Drug | Target | Type |
|---|---|---|
| Decitabine | Deoxycytidine kinase | enzyme |
| Decitabine | UMP-CMP kinase | enzyme |
| Decitabine | Nucleoside diphosphokinase | enzyme |
| Decitabine | Cytidine deaminase | enzyme |
Is deaminase an enzyme?
Adenosine deaminase (also known as adenosine aminohydrolase, or ADA) is an enzyme (EC 3.5. 4.4) involved in purine metabolism. It is needed for the breakdown of adenosine from food and for the turnover of nucleic acids in tissues. Its primary function in humans is the development and maintenance of the immune system.
What amino acids are in cytidine deaminase?
Cytidine deaminase catalyzes the hydrolytic deamination of cytidine into uridine and ammonia with a 4×1011-fold rate enhancement. Uridine is converted to the base uracil, and the ultimate catabolism of cytidine yields the amino acid β-alanine and malonyl-CoA which can enter into fatty acid biosynthesis.
What does cytidine deaminase do?
Cytidine deaminase is a key enzyme involved in the pyrimidine salvage pathway and maintains the cellular pyrimidine supply. It is encoded by the human CDA gene. In the 1960s, cytosine nucleoside analogs, such as cytarabine, were reported to contain antitumor effects.
What is activation induced cytidine deaminase?
Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2) Cell.
What class of enzyme is deaminase?
hydrolases
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is cytosine aminohydrolase. This enzyme is also called isocytosine deaminase.
What does ADA enzyme do?
The function of the adenosine deaminase enzyme is to eliminate a molecule called deoxyadenosine, which is generated when DNA is broken down. Adenosine deaminase converts deoxyadenosine, which is toxic to lymphocytes, to another molecule called deoxyinosine, which is not harmful.
What does deaminase mean?
Definition of deaminase : an enzyme that hydrolyzes amino compounds (such as amino acids) with removal of the amino group.
What active site amino acid is found in all members of the family of cytidine deaminase enzymes?
The first member of this new family is APOBEC1, which deaminates apolipoprotein B messenger RNA to generate a premature stop codon. APOBEC1 has the conserved active site motif found in Escherichia coli cytidine deaminase.
What does cytosine deaminase do?
Cytosine deaminase (CD; EC 3.5. 4.1) is responsible for the conversion of cytosine to uracil and ammonia, providing an important mechanism for pyrimidine salvage in microbes.
Where is cytidine deaminase found?
The gene encoding cytidine deaminase (CDA) is located in locus 1p36. 2-1p35 [54, 55]. CDA catalyzes the hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively, that results in the loss of their cytotoxic activity.