What are osteogenic cells?
Osteoprogenitor cells, also known as osteogenic cells, are stem cells located in the bone that play a prodigal role in bone repair and growth. These cells are the precursors to the more specialized bone cells (osteocytes and osteoblasts) and reside in the bone marrow.
What is osteoblast osteoclast osteocyte?
They line the surface of the bone. These old osteoblasts are also called LINING CELLS. They regulate passage of calcium into and out of the bone, and they respond to hormones by making special proteins that activate the osteoclasts. OSTEOCYTES are cells inside the bone. They also come from osteoblasts.
What are osteoblasts and osteocytes?
The key difference between osteoblasts and osteocytes is that osteoblasts are a type of bone cells responsible for the formation of new bones while osteocytes are a type of bone cells that maintain the bone mass.
What happens if an osteocyte dies?
Osteocyte death ultimately results in necrosis; DAMPs are released to the bone surface and promote the production of proinflammatory cytokines, which induce Rankl expression, and osteoclastogenesis is further enhanced.
What do osteocytes do in bone remodeling?
Bone remodeling has important roles in the functions of bone tissues, such as supporting the body and mineral storage. Osteocytes, which are the most abundant cells in bone tissues, detect the mechanical loading and regulate both bone formation by osteoblasts and bone resorption by osteoclasts.
What do osteogenic cells produce?
Osteogenic cells differentiate and develop into osteoblasts which, in turn, are responsible for forming new bones. Osteoblasts synthesize and secrete a collagen matrix and calcium salts.
Where do osteogenic cells reside?
| Osteocyte | |
|---|---|
| Illustration showing a single osteocyte | |
| Details | |
| Location | Bone |
| Identifiers |
What’s the difference between osteoclast and osteoblast?
The main difference between osteoblast and osteoclast is that osteoblast is involved in the formation and mineralization of bones whereas osteoclast is involved in the breakdown and resorption of bones. The osteogenic cells in bones are developed into osteoblasts.
What are osteoclasts and osteoblasts?
Osteoblast and osteoclast are the two main cells participating in those progresses (Matsuo and Irie, 2008). Osteoclasts are responsible for aged bone resorption and osteoblasts are responsible for new bone formation (Matsuoka et al., 2014). The resorption and formation is in stable at physiological conditions.
What are osteoblasts made of?
Osteoblasts are the bone-forming cells that derive from the mesenchymal stem cells of the bone marrow, which also form chondrocytes, myocytes, and adipocytes. Osteoblasts are cuboid-shaped cells that form clusters covering the bone surface.