What are the 3 roles surfactant plays in the lungs?
Table of Contents
The main functions of surfactant are as follows: (1) lowering surface tension at the air–liquid interface and thus preventing alveolar collapse at end-expiration, (2) interacting with and subsequent killing of pathogens or preventing their dissemination, and (3) modulating immune responses.
Which surfactant is present in lungs?
Surfactant is an agent that decreases the surface tension between two media. The surface tension between gaseous-aqueous interphase in the lungs is decreased by the presence of a thin layer of fluid known as pulmonary surfactant. The pulmonary surfactant is produced by the alveolar type-II (AT-II) cells of the lungs.
How does Covid 19 affect surfactant?
COVID-19 causes acute respiratory distress syndrome (ARDS) and depletes the lungs of surfactant, leading to prolonged mechanical ventilation and death. The feasibility and safety of surfactant delivery in COVID-19 ARDS patients have not been established.
Are surfactants toxic?
Surfactants can be split into two well-separated classes: toxic and mild. Ionic surfactants can be mild; non-ionic surfactants can be toxic.
What medication is given for surfactant?
List of Lung surfactants:
Drug Name | Avg. Rating | Reviews |
---|---|---|
Survanta (Pro) Generic name: beractant | 10 | No reviews |
Surfaxin (Pro) Generic name: lucinactant | 6.0 | No reviews |
Infasurf (Pro) Generic name: calfactant | 10 | No reviews |
Curosurf (Pro) Generic name: poractant | 10 | No reviews |
Does surfactant help Covid?
Conclusions. Surfactant delivery through bronchoscopy at a dose of 720 mg in 150 ml normal saline is feasible and safe for COVID-19 ARDS patients and health care providers during the pandemic.