What are the effects of beta-1 blockade?
The blockade of this pathway with beta-1 blockers results in decreased contractility (inotropy), decreased heart rate (chronotropy), increased relaxation (lusitropy), and decreased cardiac conduction times (dromotropy).
What does a beta-1 adrenergic antagonist do?
Beta-adrenergic antagonists are used to treat high blood pressure, chest pain (angina), abnormal heart rate (arrhythmia), congestive heart failure, and several other conditions. They may also shrink certain types of vascular tumors, such as hemangiomas.
What are the general effects of adrenergic blockers?
Adverse effects of the first type include bronchospasm, heart failure, prolonged hypoglycemia, bradycardia, heart block, intermittent claudication, and Raynaud’s phenomenon. Neurological reactions include depression, fatigue, and nightmares.
What effects do agents such as metoprolol have on the cardiovascular system?
This medicine is a beta-blocker. It works by affecting the response to nerve impulses in certain parts of the body, like the heart. As a result, the heart beats slower and decreases the blood pressure. When the blood pressure is lowered, the amount of blood and oxygen is increased to the heart.
What are the potential adverse effects of b1 and b2 blockers?
The blockade of these receptors with beta-blocker medications can lead to many adverse effects. Bradycardia and hypotension are two adverse effects that may commonly occur. Fatigue, dizziness, nausea, and constipation are also widely reported. Some patients report sexual dysfunction and erectile dysfunction.
How does a beta-blocker affect the heart rate and contractility?
The antianginal effects of beta-blockers are attributed to their cardiodepressant and hypotensive actions. By reducing heart rate, contractility, and arterial pressure, beta-blockers reduce the work of the heart and the oxygen demand of the heart.
Do beta-blockers block norepinephrine?
Beta blockers, also known as beta-adrenergic blocking agents, are a class of drugs that works by blocking the neurotransmitters norepinephrine and epinephrine from binding to receptors.
How do beta-blockers affect cardiac output?
Beta Blockers are drugs that slow the heart rate, decrease cardiac output, lessen the force with which the heart muscle contracts and reduce blood vessel contraction They do this by blocking beta-adrenergic receptors in various parts of the body. This prevents adrenaline (epinephrine) from stimulating these receptors.
What are beta-1 selective beta-blockers?
Beta-1 selective blockers are a subclass of beta blockers that are commonly used to treat high blood pressure. Drugs in this class include atenolol (Tenormin), metoprolol (Lopressor), nebivolol (Bystolic) and bisoprolol (Zebeta, Monocor).