What does CSPG?
CSPG. Certified Specialist in Planned Giving (American Institute for Philanthropic Studies)
What is the core protein of proteoglycans?
The basic proteoglycan unit consists of a “core protein” with one or more covalently attached glycosaminoglycan (GAG) chain(s). The point of attachment is a serine (Ser) residue to which the glycosaminoglycan is joined through a tetrasaccharide bridge (e.g. chondroitin sulfate-GlcA-Gal-Gal-Xyl-PROTEIN).
Is chondroitin sulphate A proteoglycan?
The protein can be expressed with or without covalently attached chondroitin sulfate glycosaminoglycan (GAG) and is therefore considered a “part-time” cell surface proteoglycan. Chondroitin sulfate modification of the core protein has been linked to its ability to bind the heparin-binding domain of fibronectin.
What is the key role of chondroitin sulfate proteoglycans?
Chondroitin sulfate proteoglycans (CSPGs) are extracellular matrix components that contain two structural parts with distinct functions: a protein core and glycosaminoglycan (GAG) side chains. CSPGs are known to be involved in important cell processes like cell adhesion and growth, receptor binding, or cell migration.
What are core proteins?
One of the proteins to which are attached the carbohydrate chains (e.g. chondroitin sulphate, keratan sulphate) of a proteoglycan, and which with them comprise the subunits of the proteoglycan. ( see also link protein)
What is a proteoglycan composed of?
Proteoglycans consist of a core protein and one or more covalently attached GAG chains (Figure 11.2). GAGs are linear polysaccharides, whose building blocks (disaccharides) consist of an amino sugar (either GlcNAc or GalNAc) and an uronic acid (GlcA and IdoA).
What is collagen and proteoglycan?
The organization of these macromolecules is critical: collagen molecules become assembled into fibrils, fibrils aggregate to form fibers, fibers associate into bundles of fibers, and proteoglycans in the ground substance play a major role in the ordering process; on the other hand, glycosaminoglycans (GAGs) are …
What are proteoglycans examples?
Examples of proteoglycans are versican (a large chondroitin sulfate proteoglycan), perlecan, neurocan, aggrecan, brevican, fibromodulin, and lumican.
What is proteoglycan in cartilage?
Cartilage proteoglycans are extracellular macromolecules with complex structure, composed of a core protein onto which a variable number of glycosaminoglycan chains are attached. Their biosynthesis at the glycosaminoglycan level involves a great number of sugar transferases well-orchestrated in Golgi apparatus.
What are proteoglycans quizlet?
Define Proteoglycans. a class of glycoproteins composed of many long, linear chains of glycosaminoglycans (GAGs) covalently linked to a core protein.
Is dermatan sulfate a proteoglycan?
Dermatan sulfate (DS) is a linear polysaccharide that has been classified as a sulfated glycosaminoglycan, which is covalently attached to the core proteins of proteoglycans (PGs) [1,2,3,4].
Is chondroitin A sulfate?
Chondroitin sulfate is a chemical found in human and animal cartilage. It is commonly used by mouth with glucosamine or other ingredients for osteoarthritis. Chondroitin sulfate is one of the building blocks of cartilage.