What does ER positive PR positive and HER2-negative mean?
Breast cancer groups include: Group 1 (luminal A). This group includes tumors that are ER positive and PR positive, but negative for HER2. Luminal A breast cancers are likely to benefit from hormone therapy and may also benefit from chemotherapy.
Is it better to be ER positive or negative?
Hormone receptor-positive cancers tend to grow more slowly than those that are hormone receptor-negative. Women with hormone receptor-positive cancers tend to have a better outlook in the short-term, but these cancers can sometimes come back many years after treatment.
Which has better prognosis HER2-positive or negative?
HER2-positive cancer tends to be poorer in terms of prognosis than HER2-negative cancer because: It grows faster. It is more likely to spread to the lymph nodes fast. It is at least two times more likely to return than HER2-negative tumors.
Is chemo necessary for HER2-negative?
Many women with hormone-positive, HER2-negative, lymph node-negative early-stage breast cancer who have intermediate risk of cancer recurrence do not need chemotherapy. The exception is that some women who are younger than 50 may benefit when chemotherapy is added to hormone therapy.
Does HER2-negative come back?
Because triple-negative breast cancer lacks both HER2 and hormone receptors, it doesn’t respond to treatments that target these factors. Additionally, it tends to recur more often than other subtypes of breast cancer.
Do you need chemo for HER2-negative?
Hormonal therapy is considered the standard initial treatment for HER2-negative metastatic breast cancer that is also hormone receptor-positive, and is often given in combination with targeted therapy. However, chemotherapy may also be given. A clinical trial may also be an option for treatment at any stage.
What is the difference between HER2 positive and HER2 negative cancer?
If a tumor has this property, it is called HER2-positive. HER2 positive cancers are more aggressive than HER2 negative cancer. Knowing breast cancer type, leads doctors to determining best treatments.
What is the treatment for ER positive and HER2 negative breast cancer?
The most common treatment for ER positive and HER2 negative breast cancer is hormone blocking therapy. Although chemotherapy can also be used, no specific type is recommended by the American Society for Clinical Oncology (ASCO).
What is the difference between ER positive and ER positive breast cancer?
Cancerous cells may have none, one, or both receptors. Breast cancers that have estrogen receptors are called ER-positive (or ER+). Those with progesterone receptors are referred to as PR-positive (or PR+). In addition to hormone receptors, some breast cancers have high levels of a growth-promoting protein called HER2/neu.
Why is it important to know my HER2 status?
Your HER2 status helps determine the pathology of your specific breast cancer. Your HER2 status can also help determine how aggressive the cancer is. Your doctor will use this information to evaluate your treatment options.