What is the cause of Chondrocalcinosis?
Chondrocalcinosis 2 is caused by changes in the ANKH gene . The disease is inherited in an autosomal dominant manner. Chondrocalcinosis 2 is diagnosed based on imaging such as X-rays . The diagnosis can be confirmed with genetic testing of the ANKH gene.
What is Chondrocalcinosis associated with?
Chondrocalcinosis is associated with osteoarthritis (OA) (1) and several studies have found an association between the presence of CPP crystals in synovial fluid and radiographic severity of OA (2, 3).
Is Chondrocalcinosis seen in pseudogout?
In addition, familial polyarticular chondrocalcinosis has been observed. There is a significantly high prevalence of diabetes mellitus in patients with pseudogout. 1. 2.
What causes calcium pyrophosphate crystals?
CPPD crystals may be seen associated with some underlying disorders such as injury to the joint, hyperparathyroidism, hypomagnesemia, hypophosphatasia, hypothyroidism and hemochromatosis. The abnormal formation of CPPD crystals may also be a hereditary trait.
What does crystals in the knee mean?
Many people with osteoarthritis, particularly of the knee, have these calcium crystals in their joint cartilage. This is called osteoarthritis with calcium pyrophosphate crystal deposition (osteoarthritis with CPPD for short). These crystals tend to make the symptoms of osteoarthritis worse.
How is chondrocalcinosis diagnosed?
The diagnosis of CCAL2 is based on a clinical evaluation that includes a thorough patient history and specialized laboratory tests. In one test, fluid is removed from an affected joint (synovial fluid). The presence of calcium pyrophosphate crystals in this fluid confirms the diagnosis of articular chondrocalcinosis.
What does chondrocalcinosis mean?
Chondrocalcinosis (literally calcification of the cartilage) is a term used to describe the radiological appearance of calcium pyrophosphate dihydrate crystal deposition within either fibrocartilage (e.g. menisci) or hyaline cartilage.
How is Chondrocalcinosis of the knee treated?
Healthcare providers usually recommend OTC nonsteroidal anti-inflammatory drugs (NSAIDs) and analgesic pain relievers, like acetaminophen, to manage symptoms of chondrocalcinosis attacks.
What causes Chondrocalcinosis in the knee?
The cause of abnormal deposits of CPPD crystals in cartilage is often unknown. CPPD crystals may be seen associated with some underlying disorders such as injury to the joint, hyperparathyroidism, hypomagnesemia, hypophosphatasia, hypothyroidism and hemochromatosis.