What is the major side effects of amphotericin B?
Common side effects may include:
- nausea, vomiting, stomach pain, diarrhea;
- upset stomach, loss of appetite;
- muscle or joint pain;
- headache, ringing in your ears;
- pain, bruising, or swelling where the medicine was injected;
- weight loss; or.
- flushing (warmth, redness, or tingly feeling).
What is the most serious side effect of amphotericin?
The principal acute toxicity of AmB deoxycholate includes nausea, vomiting, rigors, fever, hypertension or hypotension, and hypoxia. Its principal chronic adverse effect is nephrotoxicity.
How do you take amphotericin B?
Amphotericin B injection is usually infused (injected slowly) intravenously over a period of 2 to 6 hours once daily. Before you receive your first dose, you may receive a test dose over 20 to 30 minutes to see if you can tolerate the medication.
What are the side effects of posaconazole?
Posaconazole may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- chills or shaking.
- swelling of the hands, feet, ankles, or lower legs.
What causes amphotericin B toxicity?
Mechanism of toxicity Mammalian and fungal membranes both contain sterols, a primary membrane target for amphotericin B. Because mammalian and fungal membranes are similar in structure and composition, this is one mechanism by which amphotericin B causes cellular toxicity.
What are the side effects of AMO?
- Abdominal or stomach cramps or tenderness.
- back, leg, or stomach pains.
- black, tarry stools.
- blistering, peeling, or loosening of the skin.
- blood in the urine.
- bloody nose.
- chest pain.
How is amphotericin B toxicity treated?
Administering 500–1000 mL bolus of normal saline before and after amphotericin B infusion can reduce the incidence and severity of nephrotoxicity. (8) Fevers, chills, and rigors are also minimized by providing acetaminophen, diphenhydramine, and/or hydrocortisone 30–60 minutes prior to amphotericin B administration.
What are the side effects of vancomycin?
- Black, tarry stools.
- blood in the urine or stools.
- continuing ringing or buzzing or other unexplained noise in the ears.
- cough or hoarseness.
- dizziness or lightheadedness.
- feeling of fullness in the ears.
- fever with or without chills.
- general feeling of tiredness or weakness.
Which adverse reaction do most patients experience when receiving IV amphotericin B?
Acute reactions including fever, shaking chills, hypotension, anorexia, nausea, vomiting, headache, and tachypnea are common 1 to 3 hours after starting an intravenous infusion. These reactions are usually more severe with the first few doses of amphotericin B and usually diminish with subsequent doses.