What is the use of nikethamide?
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Nikethamide is a stimulant which mainly affects the respiratory cycle. Widely known by its former trade name of Coramine, it was used in the mid-twentieth century as a medical countermeasure against tranquilizer overdoses, before the advent of endotracheal intubation and positive-pressure lung expansion.
What is the mechanism of action of doxapram?
Doxapram stimulates the medullary respiratory centre both by a direct action and by peripheral stimulation of the carotid body. It increases respiratory drive and arousal, and improves both rate and depth of ventilation.
Is Nikethamide CNS stimulant?
Early drugs of this type such as nikethamide were used as respiratory stimulants, but at doses effective for stimulating respiration they had an unacceptably high incidence of CNS toxicity such as headache, agitation, muscle spasms or convulsions.
What is the main effect of Dopram Doxapram hydrochloride?
Doxapram hydrochloride produces respiratory stimulation mediated through the peripheral carotid chemoreceptors. As the dosage level is increased, the central respiratory centers in the medulla are stimulated with progressive stimulation of other parts of the brain and spinal cord.
What are respiratory stimulants?
Respiratory stimulants are medications used to stimulate respiration post anesthesia or to treat respiratory conditions such as chronic obstructive pulmonary disease (COPD), respiratory depression/failure, and neonatal apnea. Respiratory stimulants improve the respiratory drive and oxygen inflow as a result.
Which are the clinical uses of doxapram?
Doxapram is a respiratory stimulant and an analeptic (CNS stimulant) that is used to treat drug-induced ventilatory depression and apnoea in newborn animals and humans.
What type of drug is doxapram?
Doxapram is an analeptic agent (a stimulant of the central nervous system). The respiratory stimulant action is manifested by an increase in tidal volume associated with a slight increase in respiratory rate. A pressor response may result following doxapram administration.
Which ring is present in Nikethamide?
Nikethamide is a pyridinecarboxamide. It derives from a nicotinamide.
What is Picrotoxin used for?
Picrotoxin is a toxin obtained from the seeds of the shrub Anamirta cocculus. It is used as a central nervous system stimulant, antidote, convulsant, and GABA (gamma aminobutyric acid) antagonist.
How do respiratory stimulants work?
Respiratory stimulants improve the respiratory drive and oxygen inflow as a result. Respiratory stimulants drive respiration by stimulating the brain’s respiratory center in the medulla oblongata, located at the base of the brain.
What is Paraxanthine used for?
Pharmacology and physiological effects Like caffeine, paraxanthine is a psychoactive central nervous system (CNS) stimulant.