How long does oritavancin last?
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Pharmacokinetics and Pharmacodynamics Oritavancin displays linear pharmacokinetics when administered at intravenous (IV) doses ranging from 0.02 to 10 mg/kg. It is bound to approximately 85% of human proteins. Based on population kinetics, the half-life of oritavancin is 393 hours, allowing for a single-dose strategy.
What is oritavancin used to treat?
Oritavancin injection is used to treat acute bacterial skin and skin structure infections (ABSSSI). Oritavancin belongs to the group of medicines known as antibiotics. It works by killing bacteria or preventing their growth. Oritavancin will not work for colds, flu, or other virus infections.
What does Orbactiv cover?
ORBACTIV® (oritavancin) for injection is indicated for the treatment of adult patients with acute bacterial skin and skin structure infections (ABSSSI) caused or suspected to be caused by susceptible isolates of the following gram-positive microorganisms: Staphylococcus aureus (including methicillin-susceptible [MSSA] …
How is oritavancin eliminated?
Elimination of oritavancin from the body employs both renal and fecal routes, with renal as the major route with a very slow process (<5% of a dose is excreted in the urine over 14 days while <1% is eliminated in feces over that time), indicating a rapid tissue accumulation and prolonged retention (3).
Does vancomycin have a long half-life?
aureus, and vancomycin-resistant enterococci. The drug is administered as a single intravenous dose of 1200 mg over 3 hours in adult patients, and because of its terminal half-life of 393 hours, repeat dosing is not required in the treatment of ABSSIs.
What class of drug is vancomycin?
Vancomycin is in a class of medications called glycopeptide antibiotics.
How much does Orbactiv cost?
The approximate retail price of Orbactiv is usually around $6,029.62. Use a SingleCare Orbactiv coupon to reduce the cost of Orbactiv down to $6,544.74.
Is Orbactiv an antibiotic?
Orbactiv (oritavancin) for injection is an antibiotic used to treat adult patients with acute bacterial skin and skin structure infections (ABSSSI) caused by susceptible isolates of the following Gram-positive microorganisms: Staphylococcus aureus (including methicillin-susceptible and methicillin-resistant isolates).
What drug class is oritavancin?
Oritavancin is in a class of medications called lipoglycopeptide antibiotics. It works by killing bacteria. Antibiotics such as oritavancin will not work for colds, flu, and other viral infections.
Does vancomycin have a long half life?
Does vancomycin inhibit protein synthesis?
These antibiotics include bacitracin, glycopeptides such as vancomycin, and β-lactam antibiotics. Macrolides such as azithromycin, lincosamides (clindamycin), linezolid, chloramphenicol, aminoglycosides such as tobramycin, mupirocin, and tetracycline all inhibit protein synthesis.