What causes angiomyolipoma to grow?
Renal angiomyolipoma is caused by a genetic mutation to the TSC1 or TSC2 gene (tumor suppressor genes). They are responsible for producing tuberin, a protein that helps control cells’ growth and size. When the TSC genes mutate or change, it affects the production of tuberin, and cells may grow out of control.
Can angiomyolipoma cause hydronephrosis?
Incidental finding of a benign renal neoplasm such as Angiomyolipoma could occur in a giant hydronephrosis.
What is angiomyolipoma of the kidney symptoms?
Angiomyolipoma of the Kidney. Angiomyolipoma is a condition in which benign tumors form in your kidney. You may have no symptoms, or you may have anemia, fever, pain or high blood pressure. Tumors that grow may need treatment such as embolization or surgery to reduce the risk of bleeding.
Is angiomyolipoma considered kidney disease?
Angiomyolipomas are related to the genetic disease tuberous sclerosis. Angiomyolipomas are benign tumors of the kidney and, rarely, other organs.
Does angiomyolipoma affect kidney function?
Angiomyolipomas (AMLs) are benign fat-containing tumors that affect the kidneys. AMLs associated with the tuberous sclerosis complex (TSC) are often larger, usually bilateral, and grow more rapidly than AMLs in sporadic cases.
Can angiomyolipoma affect kidney function?
Can angiomyolipoma be removed?
Angiomyolipoma can be treated by the drug everolimus (Afinitor) that works by blocking the human target of rapamycin (mTOR) protein to affect many processes involved in cell growth. Researchers suggest that even if asymptomatic, angiomyolipoma that grows to 3 cm or more in diameter should be treated.
When should angiomyolipoma be treated?
Large asymptomatic angiomyolipomas (> 8 cm) will most likely become symptomatic and should be treated electively prior to the development of symptoms and potential complications.
Does angiomyolipoma cause pain?
However, even though they are benign tumors, some angiomyolipomas can cause symptoms and signs if the tumor becomes very large or if the blood vessels in the angiomyolipoma start to leak or rupture. In this case, symptoms such as back pain or flank pain, nausea, vomiting, anemia, or high blood pressure may occur.