What does p57 positive mean?
The p57 expression pattern was interpreted as ‘discordant’ when there was any combination/admixture of negative and positive results for villous stromal cells and cytotrophoblast within individual villi, including positive staining in cytotrophoblast and negative staining in villous stromal cells, or vice versa.
What does p57 stain?
p57(KIP2) staining can be used in concert with ploidy studies to refine the diagnosis of early molar pregnancies.
What is partial hydatidiform mole?
A partial molar pregnancy is a variation of a molar pregnancy, an abnormal pregnancy in which an embryo (the fertilized egg) either develops incompletely, or doesn’t develop at all. Instead, a cluster of grape-like cysts (known as a hydatidiform mole) grows in the uterus.
Is partial mole malignant?
There are 2 types of molar pregnancy: complete or partial. They are usually slow growing and benign, although there is a chance a mole can become cancerous. A complete molar pregnancy is much more likely to become cancerous than a partial molar pregnancy.
What is a trophoblastic tumor?
A placental-site trophoblastic tumor (PSTT) is a rare type of gestational trophoblastic neoplasia that forms where the placenta attaches to the uterus. The tumor forms from trophoblast cells and spreads into the muscle of the uterus and into blood vessels. It may also spread to the lungs, pelvis, or lymph nodes.
What is Hydropic abortion?
Hydropic abortions contain 50% of genetic material from the mother and the staining will be strong in the cytotrophoblast, mesenchymal cells, and intermediate trophoblast. Partial mole is triploid and contains approximately 66% of androgenic genetic material and 33% will be maternally derived.
What is the reason for partial hydatidiform mole?
In a partial or incomplete molar pregnancy, the mother’s chromosomes remain but the father provides two sets of chromosomes. As a result, the embryo has 69 chromosomes instead of 46. This most often occurs when two sperm fertilize an egg, resulting in an extra copy of the father’s genetic material.
Can you get pregnant after a partial molar pregnancy?
Yes, you have every chance of getting pregnant again and having a healthy baby. The risk of having another molar pregnancy is small (about 1 in 80). It’s best not to try getting pregnant again until all your follow-up treatment has finished. For most women, this will take about 6 months.
Why did I have a partial molar pregnancy?
How common is a partial molar pregnancy?
Partial molar pregnancy with a live fetus is a very rare condition, occurring in 0.005 to 0.01% of all pregnancies; it presents a challenging diagnosis, especially when clinical signs are almost completely absent.
Can GTD come back?
The risk of GTD coming back is highest in the first few months. You will need to wait a year after finishing your treatment before you try and get pregnant again, if you have chemotherapy . It’s important to know that having a GTD does not increase your risk of having a baby with abnormalities.