What is a murine model of asthma?
The murine models of allergic respiratory diseases induced by ovalbumin (OVA) and aeroallergens have been widely used to elucidate immunological and nonimmunological mechanisms involved in the pathogenesis of asthma.
What is mouse model?
A mouse model is a laboratory mouse used to study some aspect of human physiology or disease. A variety of different model organisms are used in this regard, but mice are especially useful because they share mammalian features with humans and suffer from many of the same diseases.
How do you induce asthma in mice?
To establish ovalbumin (OVA)-induced allergic asthma models, BALB/c mice were sensitized to 20 μg OVA with 1 mg aluminum hydroxide by the intraperitoneal route and then challenged by inhalation or intranasal administration with 5% OVA for 3 consecutive days.
What is asthmatic response?
Background. The inhalation of allergens by allergic asthmatics results in the early asthmatic response (EAR), which is characterized by acute airway obstruction beginning within a few minutes. The EAR is the earliest indicator of the pathological progression of allergic asthma.
What is the cause asthma?
Asthma triggers Exposure to various irritants and substances that trigger allergies (allergens) can trigger signs and symptoms of asthma. Asthma triggers are different from person to person and can include: Airborne allergens, such as pollen, dust mites, mold spores, pet dander or particles of cockroach waste.
How is neutrophilic asthma treated?
Treatment of neutrophilic asthma requires novel anti-inflammatory agents and therapeutic strategies targeted against airway smooth muscle hypertrophy and airway remodeling, such as phosphodiesterase 4 inhibitors, macrolide antibiotics and bronchial thermoplasty.
What is T2 type asthma?
Asthma can be viewed as a Type 2 (T2 high) subtype, which implicates signaling of IL-4, IL-13, Il-5, IgE and other inflammatory cascade pathways. Proposed biomarkers of T2 asthma include serum IgE, blood and lung eosinophils, exhaled nitric oxide, and others. Allergic asthma is considered a T2-high form of asthma.
What are murine tumor models?
Xenograft Mouse Models
|Disease||Cell Line||Mouse Strain|
|Breast cancer||MCF-7, T47D, MDA-MB-231||Nude, SCID|
|Prostate cancer||PC-3, DU-145||Nude|
|Ovarian cancer||OVCAR-3, OVCAR-5||Nude, SCID|
|Renal cancer||RXF-393, CakI-1, A498||Nude|
Is rat a murine?
The Old World rats and mice, part of the subfamily Murinae in the family Muridae, comprise at least 519 species. Members of this subfamily are called murines.
What does the word murine mean?
Definition of murine : of or relating to a murid genus (Mus) or its subfamily (Murinae) which includes the common household rats and mice also : of, relating to, or involving these rodents and especially the house mouse.
What animals can have asthma?
Touching or inhaling these allergens causes your immune system to overreact, leading to your asthma symptoms getting worse. Lots of pets can trigger allergic asthma symptoms, from cats, dogs and horses, to rabbits, hamsters, mice and gerbils, and birds. You might be allergic to just one type of animal or more than one.