What is RS3PE syndrome?
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RS3PE is a type of benign seronegative polyarthritis that affects older people and is characterised by sudden onset of oedema and swelling of the dorsum of the hands with symmetrical polysynovitis involving wrists, metacarpophalangeal, interphalangeal, tarsal and metatarsophalangeal joints, tenosynovitis of the flexors …
What causes RS3PE syndrome?
Although the cause of RS3PE is unknown, the following may contribute to the disease: Elevated levels of vascular endothelial growth factor and matrix metalloproteinase 3. Paraneoplastic syndrome. HLA-B7, HLA-CW7, and HLA-DQW.
Is RS3PE an autoimmune disease?
Although RS3PE is known to be a disease of the elderly population, it is also seen in young age groups, but it is extremely rare. Systemic vasculitis, autoimmune diseases, and malignancy accompany in 30% of RS3PE patients [9,10].
What is seronegative symmetrical synovitis?
Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome is a disease that commonly produces symmetrical synovitis and swelling of both the upper and lower extremities. It generally involves the wrists, hands, feet, and ankles of the affected individual.
Can PMR be unilateral?
In most patients, symptoms appear first in the shoulder girdle. In the remainder, the hip or neck are involved at onset. At presentation, symptoms may be unilateral but they usually become bilateral within a few weeks. The symptoms include pain and stiffness of the shoulder and hip girdle.
Is palindromic rheumatism curable?
There is no cure for palindromic rheumatism at the moment, but certain treatments and lifestyle changes can improve people’s symptoms, reduce the severity of attacks, and improve quality of life.
What is symmetric edema?
Remitting seronegative symmetrical synovitis with pitting edema is a disease/syndrome characterized by an acute onset of polyarthritis with pitting edema, negative rheumatoid factor, absence of joint erosions on radiographs, synovitis suggested by USG/MRI, and an exquisite response to low-dose steroids, with a …
Can PMR affect only one side?
The signs and symptoms of polymyalgia rheumatica usually occur on both sides of the body and might include: Aches or pain in your shoulders. Aches or pain in your neck, upper arms, buttocks, hips or thighs. Stiffness in affected areas, particularly in the morning or after being inactive for a time.
What diseases can mimic PMR?
What diseases mimic PMR?
- rheumatoid arthritis (RA)
- tendonitis or bursitis.
- infections.
- fibromyalgia.
- Lyme disease.
- spondyloarthropathy.
- lupus.
- vasculitis.
What triggers palindromic rheumatism?
We don’t yet know what causes the inflammation in palindromic rheumatism. Although there may be genetic links, other triggers are likely to play a part, such as infection, hormones or injury. Palindromic rheumatism affects women and men equally. The condition can start at any age, but it rarely affects children.
Is palindromic rheumatism serious?
Palindromic arthritis can cause severe discomfort, particularly if the attacks are frequent or lasting. In some people, it can lead to conditions such as rheumatoid arthritis, which can cause permanent damage to joints.
What is seronegative symmetrical polyarthritis?