Which HLA not I extravillous trophoblast?
We confirm that primary villous trophoblast cells are HLA null whereas extravillous trophoblast cells express HLA-C, HLA-G and HLA-E, but not HLA-A, HLA-B or HLA-DR molecules in normal pregnancy.
What is the role of HLA-G?
HLA-G has a key role in establishing fetal–maternal tolerance and acceptance of solid organ grafts. HLA-G has restricted tissue expression regulated at both the transcriptional and posttranscriptional level.
What are trophoblastic cells?
Trophoblasts (from Greek to feed: threphein) are cells forming the outer layer of a blastocyst, which provides nutrients to the embryo, and develops into a large part of the placenta. They are formed during the first stage of pregnancy and are the first cells to differentiate from the fertilized egg.
Where are trophoblast cells located?
Trophoblast cells, components of the outermost membrane, are located next to the maternal endometrium and must exhibit invasive properties to form an effective maternal–fetal vascular relationship.
Does cytotrophoblast produce hCG?
Cytotrophoblast cells naturally produce hyperglycosylated hCG, which promotes their growth and invasion. Other cells need to be transformed to produce invasive hyperglycosylated hCG.
What is HLA E?
HLA-E is an important modulator of natural killer (NK) and cytotoxic T lymphocyte (CTL) activation and inhibitory function and is the best studied of the nonclassical HLA molecules (Pietra et al., 2009). HLA-E has a role in both the innate and adaptive immune responses.
Are trophoblasts epithelial cells?
Trophoblasts (from Greek to feed: threphein) are cells forming the outer layer of a blastocyst, which provides nutrients to the embryo, and develops into a large part of the placenta. The syncytiotrophoblasts are a continuous, specialized layer of epithelial cells.
What role do trophoblasts play?
Trophoblasts are cells that form the outer layer of a blastocyst, which provides nutrients to the embryo, and then develop into a large part of the placenta. Trophoblast invasion is a critical process in the establishment of a successful pregnancy.
What are trophoblasts?
(TROH-foh-BLAST) A thin layer of cells that helps a developing embryo attach to the wall of the uterus, protects the embryo, and forms a part of the placenta.